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HOME
> 種原資料庫 >
RMRC12006
RMRC No.
RMRC12006
Order
Strain/Stock Designation
NOD/ShiLtJNarl
Status
EM
|
(Cryopreserved Embryos)
Availability
Level4
Pricing
(Cryo Recovery) International:760USD
Last Update Date
2025/2/17
Analysis Data
Description
Genes &
alleles
Phenotype
Health &
husbandry
References
Specific Term
and Conditions
Construct map
Species
:
laboratory mouse
Strain Type
:
MSR (mutant strain),IS (inbred strain)
Mutant Type
:
Other Names
:
Background Strain
:
Strain Description
:
胰臟炎,胰島受到白血球浸潤。
聽力隨年齡增長變差(3月聽力已嚴重喪失)。
抗原呈現細胞(antigen-presenting cell)功能的缺陷;T淋巴球調節功能缺陷;NK cell功能缺陷;巨噬細胞不分泌細胞激素(cytokines);缺乏補體C5。
糖尿病發病特徵具性別差異性,雌性發生年齡較早,且比率高於雄性,故研究時常用雌鼠。於30週齡時,雌性有90-100%發病,雄性在30-40週齡僅有40-60%的發病率。雌性在12週齡時體內胰島素含量開始降低,而雄鼠則晚雌鼠數週後表現。症狀會產生糖尿、血糖過高(超過250mg/dl) 。
神經學研究:聽力缺陷。
發生學研究:淋巴組織缺陷、造血功能缺陷。
第I型糖尿病及肥胖研究。
免疫學及炎症研究:NK cell缺陷。
傷口癒合研究-傷口癒合時間長。
Depositor
:
/
Email
:
Allele Symbol
:
Allele Name
:
Allele Description
:
Strain of Origin
:
Gene Symbol
:
Gene Name
:
Chromosome
:
Genotyping Method
:
Genotyping NLAC
:
Research Application
:
Construction Technologies
:
Animal Health Reports
:
Colony Maintenance
Breeding & Husbandry
:
Colony Maintenance
Mating System
:
References
:
Specific Terms of Use
:
無特別規定
寄存者對於分讓申請人使用本材料所獲得之研究成果,不主張任何專利、智慧財產權及其他財產權
DEPOSITOR waives its own rights under any patents, intellectual property, or other proprietary rights with respect to the results to be obtained by use of BIOLOGICAL RESOURCE.
Construct Map
:
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