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RMRC No. RMRC13431 Order
Strain/Stock Designation C57BL/6-Tg(CAGGS-ACE2)32Narl/Narl
Status
SP| (Cryopreserved or freeze-dried sperm)
Availability
Pricing Industry：23,680NTD　Academia: 23,680NTD　NSTC: 16,580NTD
Last Update Date 2025/5/22
Analysis Data
  • Description
  • Genes &
    alleles
  • Phenotype
  • Health &
    husbandry
  • References
  • Specific Term
    and Conditions
  • Construct map
Species ： laboratory mouse
Strain Type ： COI (coisogenic strain),MSR (mutant strain)
Mutant Type ： TG (Transgenic)
Other Names ： CAG-hACE2
Background Strain ： C57BL/6
Strain Description ：
1.  This strain harbors a plasmid-based transgene engineered to overexpress human ACE2 under the control of the ubiquitous CAGGS promoter. The construct was injected into C57BL/6J embryos with the aim of enabling hACE2-mediated viral entry and potentially modeling the pathological symptoms of SARS-CoV-2 infection in transgenic mice.
2.  Although the actual infection experiment has not yet been conducted, expression of human ACE2 protein in transgenic mouse tissues—including brain, intestine, heart, lung, and kidney—has been confirmed by both Western blotting and immunohistochemical staining using an ACE2-specific antibody (GeneTex, Cat. No. GTX636265).
Depositor ：
National Center for Biomodels, National Institutes of Applied Research / 財團法人國家實驗研究院國家生物模式中心
Email ： bujiii@niar.org.tw
Allele Symbol ： Tg(CAGGS-ACE2)32Narl
Allele Name ： transgenic insertion 32, National Applied Research Laboratories
Allele Description ：
Strain of Origin ： C57BL/6
Gene Symbol ： Ace2
Gene Name ： angiotensin converting enzyme 2
Chromosome ： UN
Genotyping Method ： Download            
Genotyping NLAC ：            
Research Application ：
Immunology and Inflammation Pharmacology and Toxicology
Virology
Construction Technologies ： No
Animal Health Reports ：
Colony Maintenance
Breeding & Husbandry 		：
Colony Maintenance
Mating System 		： hetero/hemi x wild type
References ： No

Specific Terms of Use ：
有特別規定
本生物材料僅限使用於學術研究。寄存者對於分讓申請人使用本材料 所獲得之研究成果，不主張任何專利、智慧財產權及其他財產權
DEPOSITOR waives its own rights under any patents, intellectual property, or other proprietary rights with respect to the results to be obtained by use of BIOLOGICAL RESOURCE for academic research purpose.
分讓申請人公開發表使用本材料所獲得之論文或其他研究成果時，應揭露並致謝本材料係由財團法人國家實驗研究院國家生物模式中心所提供
Should the use of this material result in one or more scientific publication(s) the Recipient Investigator agrees to mention and acknowledge NCB, NIAR
Construct Map ：
 
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