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RMRC No. RMRC13080 Order
Strain/Stock Designation B6.129-Cyp11a1tm2Bcc/Narl
Status
EM| (Cryopreserved Embryos)
Availability Level4
Pricing (Embryos) 　International：560USD
(Cryo Recovery) 　International：760USD
Last Update Date 2024/2/5
Analysis Data
  • Description
  • Genes &
    alleles
  • Phenotype
  • Health &
    husbandry
  • References
  • Specific Term
    and Conditions
  • Construct map
Species ： laboratory mouse
Strain Type ： MSK (mutant stock)
Mutant Type ： TM (Target Mutation)
Other Names ：
Background Strain ： C57BL/6
Strain Description ：
1.  The targeting vector contained mutant sequence in the proximal SF-1 binding site of Cyp11a1 (TAGCCTTGA was replaced with TAGaaTTGA), an insertion of the loxP-flanked neo gene in intron 1, was introduced into 129 embryonic stem cells by homologous recombination followed by blastocyst injection. The neo gene was removed by EIIa-cre-mediated recombination. One and halfloxP sites in the intron1 ofCyp11a1 were left after cre-mediated recombination. This strain has been backcrossed to C57BL/6 for more than ten generation.
2.  Homozygous mutant mice showed blunted HPA-axis stress response.
3.  This strain expressed about 7-fold less Cyp11a1 in the adrenal and testis but expressed normal amounts of Cyp11a1 in the placenta and ovary. This tissue-specific reduction did not affect basal steroid secretion but attenuated the circadian rhythm of glucocorticoid secretion.
Depositor ：
Chung, Bon-chu / 鍾邦柱
Email ：
Allele Symbol ： Cyp11a1tm2Bcc
Allele Name ： cytochrome P450, family 11, subfamily a, polypeptide 1, target mutation 2, Bon-chu Chung
Allele Description ：
Strain of Origin ： 129
Gene Symbol ： Cyp11a1
Gene Name ： cytochrome P450, family 11, subfamily a, polypeptide 1
Chromosome ： 9 (+ strand)
Genotyping Method ： Download            
Genotyping NLAC ：            
Research Application ：
Immunology and Inflammation Cell and Developmental Biology
Metabolism Neurobiology Research
Diabetes and Obesity Endocrine
Reproductive Biology Genetics Research
Construction Technologies ： No
Animal Health Reports ：
Colony Maintenance
Breeding & Husbandry 		：
Colony Maintenance
Mating System 		： hetero x hetero
References ： PubMed ID: 18174359

Specific Terms of Use ：
有特別規定
本生物材料僅限使用於學術研究。寄存者對於分讓申請人使用本材料 所獲得之研究成果，不主張任何專利、智慧財產權及其他財產權
DEPOSITOR waives its own rights under any patents, intellectual property, or other proprietary rights with respect to the results to be obtained by use of BIOLOGICAL RESOURCE for academic research purpose.
分讓申請人公開發表使用本材料所獲得之論文或其他研究成果時，應引用下述已發表之論文： Mol Endocrinol. 2008 Apr;22(4):915-23.
Should the use of this material result in one or more scientific
publication(s) the recipient agrees to cite the paper(s)： Mol Endocrinol. 2008 Apr;22(4):915-23.
分讓申請人向國研院動物中心國家實驗鼠種原庫(NLAC-RMRC)申請本材料時，應附上寄存人簽名之授權分讓同意書作為附件；NLAC- RMRC 在取得寄存人書面同意後，始進行此材料之分讓。
The recipient should obtain a written consent from the depositor of the BIOLOGICAL RESOURCE, prior to NLAC-RMRC accepting the material distribution request.
Depositor Email:
Construct Map ：
 
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