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RMRC No. RMRC13399 Order
Strain/Stock Designation C57BL/6N-Tg(BGLAP-Mir29a)Wfs/Narl
Status
EM| (Cryopreserved Embryos)
Availability Level4
Pricing (Embryos) 　International：560USD
(Cryo Recovery) 　International：760USD
Last Update Date 2023/8/21
Analysis Data
  • Description
  • Genes &
    alleles
  • Phenotype
  • Health &
    husbandry
  • References
  • Specific Term
    and Conditions
  • Construct map
Species ： laboratory mouse
Strain Type ： COI (coisogenic strain),MSR (mutant strain)
Mutant Type ： TG (Transgenic)
Other Names ：
Background Strain ： C57BL/6
Strain Description ：
1.  The linear designed construct composed of human osteocalcin (OCN) promoter and Mir29a precursor full-length sequence was transferred into fertilized eggs from C57BL/6N mice.
2.  RT-quantitative PCR confirmed that Mir29a expression in skeleton rather than other tissues was significantly increased compared to wild-type mice.
3.  Mice overexpression mir29a in osteoblasts driven by osteocalcin promoter displayed higher bone mineral density, trabecular volume and mineral acquisition than wild-type mice.
4.  Mir29a overexpression attenuated the estrogen loss-mediated excessive osteoblast surface histology, osteoclast formation of bone marrow macrophages, receptor activator nuclear factor-κligand (RANKL) and C-X-C motif chemokine ligand 12 (CXCL12) expression.
Depositor ：
Feng-Sheng Wang / 王逢興
Email ： wangfs@ms33.hinet.net
Allele Symbol ： Tg(BGLAP-Mir29a)Wfs
Allele Name ： transgenic insertion, Feng-Sheng Wang
Allele Description ：
Strain of Origin ： C57BL/6
Gene Symbol ： BGLAP
Gene Name ： bone gamma carboxyglutamate protein
Chromosome ： UN
Gene Symbol ： Mir29a
Gene Name ： microRNA 29a
Chromosome ： UN
Genotyping Method ： Download            
Genotyping NLAC ：            
Research Application ：
Apoptosis Immunology and Inflammation
Metabolism Diabetes and Obesity
Genetics Research
Construction Technologies ： No
Animal Health Reports ：
Colony Maintenance
Breeding & Husbandry 		：
Colony Maintenance
Mating System 		： homo x homo
References ： PubMed ID: 31543513

Specific Terms of Use ：
有特別規定
本生物材料僅限使用於學術研究。寄存者對於分讓申請人使用本材料 所獲得之研究成果，不主張任何專利、智慧財產權及其他財產權
DEPOSITOR waives its own rights under any patents, intellectual property, or other proprietary rights with respect to the results to be obtained by use of BIOLOGICAL RESOURCE for academic research purpose.
分讓申請人公開發表使用本材料所獲得之論文或其他研究成果時，應引用下述已發表之論文： Cell Death Dis. 2019 Sep 23;10(10):705.
Should the use of this material result in one or more scientific
publication(s) the recipient agrees to cite the paper(s)： Cell Death Dis. 2019 Sep 23;10(10):705.
分讓申請人公開發表使用本材料所獲得之論文或其他研究成果時，應揭露並致謝本材料係由Core Lab. for Phenomics and Diagnostics, Kaohsiung Chang Gung Memorial Hospital, Taiwan所提供
Should the use of this material result in one or more scientific publication(s) the Recipient Investigator agrees to mention and acknowledge Core Lab. for Phenomics and Diagnostics, Kaohsiung Chang Gung Memorial Hospital, Taiwan
分讓申請人向國研院動物中心國家實驗鼠種原庫(NLAC-RMRC)申請本材料時，應附上寄存人簽名之授權分讓同意書作為附件；NLAC- RMRC 在取得寄存人書面同意後，始進行此材料之分讓。
The recipient should obtain a written consent from the depositor of the BIOLOGICAL RESOURCE, prior to NLAC-RMRC accepting the material distribution request.
Depositor Email: wangfs@ms33.hinet.net
Construct Map ：
 
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