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RMRC No. RMRC13348 Order
Strain/Stock Designation C57BL/6-Arhgap39tm1c(EuCOMM)Wtsi/CmsNarl
Status
EM| (Cryopreserved Embryos)
Availability Level4
Pricing (Embryos) 　International：560USD
(Cryo Recovery) 　International：760USD
Last Update Date 2018/1/22
Analysis Data
  • Description
  • Genes &
    alleles
  • Phenotype
  • Health &
    husbandry
  • References
  • Specific Term
    and Conditions
  • Construct map
Species ： laboratory mouse
Strain Type ： COI (coisogenic strain),MSR (mutant strain)
Mutant Type ： TM (Target Mutation)
Other Names ：
Background Strain ： C57BL/6
Strain Description ：
1. 
The embryonic stem cells obtained from Internal Mouse Phenotyping Consortium (IMPC) was injected into C57BL/6 blastocyst to generate the chimeric mice. The male chimeric mouse was backcrossed to C57BL/6J females to generated Arhgap39 knockout-first F1 offspring. Conditional alleles, loxP-flanked exon 5 of Arhgap39, were derived by removing Frt-flanked cassette via Flp recombinase.
2.  This strain carried conditional alleles is viable.
3.  Homozyous for Arhgap39 knockout-first alleles died at early embryonic stage.
4. 
The numbers of intersections between dendritic branches and the concentric balls were significantly reduced in both apical and basilar dendrites of CA1 neurons in mice which carried removal of loxP-flanked exon 5 of Arhgap39 in neuronal-specific cells.
Depositor ：
Mau-Sun Chang / 張茂山
Email ： mschang@ntu.edu.tw
Allele Symbol ： Arhgap39tm1c(EuCOMM)Wtsi
Allele Name ： Rho GTPase activating protein 39, target mutation 1c, Wellcome Trust Sanger Institute
Allele Description ：
Strain of Origin ： C57BL/6
Gene Symbol ： Arhgap39
Gene Name ： Rho GTPase activating protein 39
Chromosome ： 15
Genotyping Method ： Download            
Genotyping NLAC ：            
Research Application ：
Cell and Developmental Biology Neurobiology Research
Construction Technologies ：
Cre-lox system
Animal Health Reports ：
Colony Maintenance
Breeding & Husbandry 		： No
Colony Maintenance
Mating System 		： homo x hetero/hemi
References ： PubMed ID: 28368047

Specific Terms of Use ：
有特別規定
本生物材料僅限使用於學術研究。寄存者對於分讓申請人使用本材料 所獲得之研究成果，不主張任何專利、智慧財產權及其他財產權
DEPOSITOR waives its own rights under any patents, intellectual property, or other proprietary rights with respect to the results to be obtained by use of BIOLOGICAL RESOURCE for academic research purpose.
分讓申請人公開發表使用本材料所獲得之論文或其他研究成果時，應引用下述已發表之論文： lee et al. Sci Rep 2017 7:45646.
Should the use of this material result in one or more scientific
publication(s) the recipient agrees to cite the paper(s)： Lee et al. Sci Rep 2017 7:45646.
Construct Map ：
 
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