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RMRC No. RMRC13202 Order
Strain/Stock Designation B6.129P2‐Adra2ctm1(lacZ)Acch
Status
EM| (Cryopreserved Embryos)
Availability Level4
Pricing (Embryos) 　International：560USD
(Cryo Recovery) 　International：760USD
Last Update Date 2015/12/18
Analysis Data
  • Description
  • Genes &
    alleles
  • Phenotype
  • Health &
    husbandry
  • References
  • Specific Term
    and Conditions
  • Construct map
Species ： laboratory mouse
Strain Type ： MSK (mutant stock),CON (congenic strain)
Mutant Type ： TM (Target Mutation)
Other Names ：
Background Strain ： C57BL/6
Strain Description ： 1. In homozygotes, the spatial expression pattern of Adra2c is mapped to cortex, anterior olfactory nucleus , olfactory tubercle, claustrum, ventral striatum, caudal caudate‐putmen, dorsal and ventral hippocampus, bed nucleus of the stria terminalis and amygdale etc.
2. Characteristics of homozygotes are as follows,
(A) Exhibit reduced sensitivity to cocaine rewarding (conditional place preference‐CPP).
(B) Reduced behavior despair, (reduced immobility in forced swimming task (FST) under chronic immobilized stress
(C) Exhibit much enhanced level of aggression (isolation induced resident‐intruder task) and anxiety (elevated plus maze, Novelty suppressed feeding, Novelty seeking), respectively
(D) Perform better in both context‐ and cue associated emotional memory under chronic immobilized stress (Pavlovian fear conditioning task).
Depositor ：
Alice Chien Chang / 錢嘉韻
Email ：
Allele Symbol ： Adra2ctm1(lacZ)Acch
Allele Name ： adrenergic receptor, alpha 2c, target mutation 1, Alice Chien Chang
Allele Description ：
Strain of Origin ： 129
Gene Symbol ： Adra2c
Gene Name ： adrenergic receptor, alpha 2c
Chromosome ： 5
Genotyping Method ： Download            
Genotyping NLAC ：            
Research Application ：
Neurobiology Research Pharmacology and Toxicology
Construction Technologies ：
LacZ
Animal Health Reports ：
Colony Maintenance
Breeding & Husbandry 		：
Colony Maintenance
Mating System 		： hetero/hemi x hetero/hemi
References ： No

Specific Terms of Use ：
有特別規定
本生物材料僅限使用於學術研究。寄存者對於分讓申請人使用本材料 所獲得之研究成果，不主張任何專利、智慧財產權及其他財產權
DEPOSITOR waives its own rights under any patents, intellectual property, or other proprietary rights with respect to the results to be obtained by use of BIOLOGICAL RESOURCE for academic research purpose.
分讓申請人公開發表使用本材料所獲得之論文或其他研究成果時，應揭露並致謝本材料係由錢嘉韻教授所提供
Should the use of this material result in one or more scientific publication(s) the Recipient Investigator agrees to mention and acknowledge Dr. Alice Chien Chang
分讓申請人向國研院動物中心國家實驗鼠種原庫(NLAC-RMRC)申請本材料時，應附上寄存人簽名之授權分讓同意書作為附件；NLAC- RMRC 在取得寄存人書面同意後，始進行此材料之分讓。
The recipient should obtain a written consent from the depositor of the BIOLOGICAL RESOURCE, prior to NLAC-RMRC accepting the material distribution request.
Depositor Email:
Construct Map ：
 
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