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RMRC No. RMRC13441 Order
Strain/Stock Designation C57BL/6-Apoeem1(APOE*2)Narl/Narl
Status
SP| (Cryopreserved or freeze-dried sperm)
Availability Level4
Pricing Industry:23,680NTD Academia: 23,680NTD NSTC: 16,580NTD
Last Update Date 2026/2/23
Analysis Data
  • Description
  • Genes &
    alleles
  • Phenotype
  • Health &
    husbandry
  • References
  • Specific Term
    and Conditions
  • Construct map
Species laboratory mouse
Strain Type COI (coisogenic strain),IS (inbred strain)
Mutant Type TM (Target Mutation)
Other Names APOE2 Knockin
Background Strain C57BL/6JNarl
Strain Description
1.  This strain is derived fromRMRC13440 C57BL/6-Apoeem1(APOE*4, APOE*2)Narl/Narlthrough direct injection of the Dre mRNA at embryo stage,which resulted in deletion of rox-flanked human APOE4 alleles and exclusive human APOE2 expression.
2.  This strain can only express human APOE2 protein without endogenous mouse Apoe expression that serves as functional human APOE2 knock-in mouse model.
Depositor
National Center for Biomodels, National Institutes of Applied Research / 財團法人國家實驗研究院國家生物模式中心
Email bujiii@narlabs.org.tw
Allele Symbol Apoeem1(APOE*2)Narl
Allele Name apolipoprotein E,endonuclease-mediated mutation 1 (APOE*2),National Applied Research Laboratories
Allele Description
Strain of Origin C57BL/6JNarl
Gene Symbol Apoe
Gene Name apolipoprotein E
Chromosome 7
Genotyping Method Download            
Genotyping NLAC            
Research Application
Cardiovascular Metabolism
Neurobiology Research
Construction Technologies
3XFlag Tag
Animal Health Reports
Colony Maintenance
Breeding & Husbandry
Colony Maintenance
Mating System
homo x homo
References No

Specific Terms of Use
有特別規定
本生物材料僅限使用於學術研究。寄存者對於分讓申請人使用本材料 所獲得之研究成果,不主張任何專利、智慧財產權及其他財產權
DEPOSITOR waives its own rights under any patents, intellectual property, or other proprietary rights with respect to the results to be obtained by use of BIOLOGICAL RESOURCE for academic research purpose.
分讓申請人公開發表使用本材料所獲得之論文或其他研究成果時,應揭露並致謝本材料係由NCB, NIAR所提供
Should the use of this material result in one or more scientific publication(s) the Recipient Investigator agrees to mention and acknowledge NCB, NIAR
Construct Map
 
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