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RMRC No. RMRC13430 Order
Strain/Stock Designation C57BL/6-Tg(Oog1,-cre; CAGGS-flEmGFP-TyrmiR)19Narl/Narl
Status
LM| (Live Animal)
Availability Level3
Pricing Industry：6,305NTD　Academia: 6,305NTD　NSTC: 4,415NTD
Last Update Date 2025/5/22
Analysis Data
  • Description
  • Genes &
    alleles
  • Phenotype
  • Health &
    husbandry
  • References
  • Specific Term
    and Conditions
  • Construct map
Species ： laboratory mouse
Strain Type ： COI (coisogenic strain),MSR (mutant strain)
Mutant Type ： TG (Transgenic)
Other Names ： Oog1-Cre
Background Strain ： C57BL/6
Strain Description ：
1.  Transgenic mice carry the BAC-based Oog1 transgene that is engineered to co-express Cre recombinase upon transcriptional activation of Oog1, utilizing an additional IRES sequence for simultaneous translation. In parallel, an independent transcription unit drives the overexpression of GFP under the control of the ubiquitous CAGGS promoter. The GFP cassette is flanked by two loxP sites, allowing it to be excised and replaced with a microRNA targeting mouse tyrosinase upon Cre-mediated recombination. As a result, this recombination event may also alter the coat color of the transgenic mice, changing it from black to gray.The offspring with a gray coat color were observed to have the transgene (cre). Also, the occurrence of gray pups is much lower than usual.
2. 
GFP expression can be visually detected from the neonatal stage, allowing for the identification of transgene-positive pups.
3.  In female hemizygous transgenic mice, every oocyte exhibits maternal Cre activity during oogenesis, enabling Cre-loxP recombination after fertilization—even in embryos that do not inherit the Oog1-Cre transgene. This strain is particularly useful when transient Cre activity is desired to eliminate paternally derived floxed alleles in early embryos without passing on the Cre transgene to the offspring. As a result, breeding time and the number of animals required for subsequent removal of the Cre transgene can be significantly reduced by mating with females of this strain.
Depositor ：
National Center for Biomodels, National Institutes of Applied Research / 財團法人國家實驗研究院國家生物模式中心
Email ： bujiii@nair.org.tw
Allele Symbol ： Tg(Oog1,-cre; CAGGS-flEmGFP-TyrmiR)19Narl
Allele Name ： transgenic insertion 19, National Applied Research Laboratories
Allele Description ：
Strain of Origin ： C57BL/6
Gene Symbol ： Oog1
Gene Name ： oogenesin 1
Chromosome ： UN
Genotyping Method ： Download            
Genotyping NLAC ：            
Research Application ：
Apoptosis Hematology
Cancer Immunology and Inflammation
Cardiovascular Internal/ Organ
Cell and Developmental Biology Metabolism
Dermatology Neurobiology Research
Diabetes and Obesity Pharmacology and Toxicology
Endocrine Reproductive Biology
Genetics Research Virology
Construction Technologies ：
Cre-lox system fluorescent proteins
Animal Health Reports ：
Colony Maintenance
Breeding & Husbandry 		：
Colony Maintenance
Mating System 		： hetero/hemi x wild type
References ： No

Specific Terms of Use ：
有特別規定
本生物材料僅限使用於學術研究。寄存者對於分讓申請人使用本材料 所獲得之研究成果，不主張任何專利、智慧財產權及其他財產權
DEPOSITOR waives its own rights under any patents, intellectual property, or other proprietary rights with respect to the results to be obtained by use of BIOLOGICAL RESOURCE for academic research purpose.
分讓申請人公開發表使用本材料所獲得之論文或其他研究成果時，應揭露並致謝本材料係由財團法人國家實驗研究院國家生物模式中心所提供
Should the use of this material result in one or more scientific publication(s) the Recipient Investigator agrees to mention and acknowledge NCB, NIAR
Construct Map ：
 
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