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RMRC No. RMRC13020 Order
Strain/Stock Designation FVB/N-Tg(ASS-Ex16-EGFP)16FTssu/Narl
Status
EM| (Cryopreserved Embryos)
Availability Level4
Pricing (Embryos) 　Industry：11,105NTD　Academia: 7,775NTD　NSTC: 5,415NTD
(Cryo Recovery) 　Industry：20,815NTD　Academia: 13,880NTD　NSTC: 13,880NTD
Last Update Date 2016/12/12
Analysis Data
  • Description
  • Genes &
    alleles
  • Phenotype
  • Health &
    husbandry
  • References
  • Specific Term
    and Conditions
  • Construct map
Species ： laboratory mouse
Strain Type ： COI (coisogenic strain),MSR (mutant strain)
Mutant Type ： TG (Transgenic)
Other Names ：
Background Strain ： FVB/N
Strain Description ：
1.  The transgene expressed ASS and EGFP as bicistronic transcript. EGFP expression is controlled transcriptionally and posttranscriptionally similar to that of the endogenous ASS gene.
2.  ASS is a rate-limiting enzyme in arginine biosynthesis and play the critical role in the production of nitric oxide. Conceivably, ASS gene expression is complex and dynamic. Particularly the post-transcriptional regulation has been shown to operate in ASS expression. The transgenic mouse system is with modified bacterial artificial chromosome (BAC) carrying ASS gene tagged with coding sequence of EGFP. 
3.  The ASS expression profile can be visualized and serves as basis to dissect mechanisms of developmental-specific, tissue-specific ASS regulation. Questions such as physiological response of ASS expression stimulated with a variety of signals can be addressed. 
4.  Among lines with EGFP knock-in at exon 16 of ASS gene, Tg(ASS-Ex16-EGFP)16FTsu? has about 5 copies of transgene.
Depositor ：
Tsung-Sheng Su / 蘇宗笙
Email ：
Allele Symbol ： Tg(ASS-Ex16-EGFP)16FTssu
Allele Name ： Transgene insertion 16F, Tsung-Sheng Su
Allele Description ：
Strain of Origin ： FVB/N
Gene Symbol ： ASS
Gene Name ： human argininosuccinate synthetase
Chromosome ： UN
Genotyping Method ：            
Genotyping NLAC ：            
Research Application ：
Apoptosis Cancer
Immunology and Inflammation Cardiovascular
Cell and Developmental Biology Metabolism
Neurobiology Research Diabetes and Obesity
Construction Technologies ：
fluorescent proteins
Animal Health Reports ：
Colony Maintenance
Breeding & Husbandry 		：
Colony Maintenance
Mating System 		： hetero/hemi x wild type
References ： PubMed ID: 25616743
PubMed ID: 24884799
Specific Terms of Use ：
有特別規定
本生物材料僅限使用於學術研究。寄存者對於分讓申請人使用本材料 所獲得之研究成果，不主張任何專利、智慧財產權及其他財產權
DEPOSITOR waives its own rights under any patents, intellectual property, or other proprietary rights with respect to the results to be obtained by use of BIOLOGICAL RESOURCE for academic research purpose.
分讓申請人公開發表使用本材料所獲得之論文或其他研究成果時，應引用下述已發表之論文： J Biomed Sci. 2014,13;21:42.; J Biomed Sci. 2015 Jan 23;22(1):10
Should the use of this material result in one or more scientific
publication(s) the recipient agrees to cite the paper(s)： J Biomed Sci. 2014,13;21:42.; J Biomed Sci. 2015 Jan 23;22(1):10
分讓申請人公開發表使用本材料所獲得之論文或其他研究成果時，應揭露並致謝本材料係由Tsung-Sheng Su所提供
Should the use of this material result in one or more scientific publication(s) the Recipient Investigator agrees to mention and acknowledge Tsung-Sheng Su
Construct Map ：
 
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