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RMRC No. RMRC13380 Order
Strain/Stock Designation CByJNarl(B6NTacTcu)-tsl/Narl
Status
EM| (Cryopreserved Embryos)
Availability Level4
Pricing (Embryos) 　Industry：11,105NTD　Academia: 7,775NTD　NSTC: 5,415NTD
(Cryo Recovery) 　Industry：20,815NTD　Academia: 13,880NTD　NSTC: 13,880NTD
Last Update Date 2023/3/23
Analysis Data
  • Description
  • Genes &
    alleles
  • Phenotype
  • Health &
    husbandry
  • References
  • Specific Term
    and Conditions
  • Construct map
Species ： laboratory mouse
Strain Type ： MSK (mutant stock),CON (congenic strain)
Mutant Type ： spontaneous mutation
Other Names ： CBy tremor
Background Strain ： BALB/cByJNarl
Strain Description ：
1.  The mutation originates on inbred strain “BALB/cByJNarl”, is crossed out to “C57BL/6NTacTcu” for three generations, then, is crossed back to the original stain for 18 generations.
2.  Homozygous died within 44 days after birth and had following clinical phenotype, (a) begin to show tremor or ataxia around 10 to 14 days of age, (b) have a short lifespan (average is 38 days; maximum 44 days), (c) low growth rate (max body weight at death is only 10 gm), (d) have pale skin and mucosa (indicating anemia) (e) may show seizure prior to death.
3.  In histopathological examination, when comparing mutants with sex-matched wildtype littermates, homozygotes have data as follows, (a) have hypomyelination in CNS only; (b) may show low hematopoietic activity in either bone marrow or spleen or liver; (c) vacuolization in skeletal and caridiac muscle cells, hepatocytes, renal tubular cells, enterocytes etc. may indicate the results of wasting syndrome.
4.  The mutation is mapped on chr.11:75,340,406-75,534,922.
Depositor ：
Ming-Hseng Marvin Wang / 王明升
Email ： wangmh@mail.tcu.edu.tw
Allele Symbol ：
Allele Name ：
Allele Description ：
Strain of Origin ： BALB/cByJNarl
Gene Symbol ：
Gene Name ：
Chromosome ：
Genotyping Method ：            
Genotyping NLAC ：            
Research Application ：
Cell and Developmental Biology Neurobiology Research
Genetics Research
Construction Technologies ： No
Animal Health Reports ：
Colony Maintenance
Breeding & Husbandry 		：
Colony Maintenance
Mating System 		： hetero/hemi x hetero/hemi
References ： No

Specific Terms of Use ：
有特別規定
本生物材料僅限使用於學術研究。寄存者對於分讓申請人使用本材料 所獲得之研究成果，不主張任何專利、智慧財產權及其他財產權
DEPOSITOR waives its own rights under any patents, intellectual property, or other proprietary rights with respect to the results to be obtained by use of BIOLOGICAL RESOURCE for academic research purpose.
分讓申請人公開發表使用本材料所獲得之論文或其他研究成果時，應揭露並致謝本材料係由Ming-Hseng Marvin Wang, DVM, Ph.D.所提供
Should the use of this material result in one or more scientific publication(s) the Recipient Investigator agrees to mention and acknowledge Ming-Hseng Marvin Wang, DVM, Ph.D.
Construct Map ：
 
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